Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093899 | 0.74 | CYP2C9 (0.41) | EGFRMETALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1093531 | 0.73 | EGFR (0.36) | KMT2AEGFRMETALDH1A1 | |
| SCHEMBL1085903 | 0.70 | RPS6KA5 (0.40) | RAB9AKMT2AEGFRMETMEN1 | |
| SCHEMBL7110475 | 0.69 | HTR1A (0.53) | RAB9ANPC1KMT2AHTR1AADRA1D | |
| SCHEMBL26921178 | 0.67 | ALDH1A1 (0.57) | RAB9ANPC1KMT2ARECQLALDH1A1 | |
| SCHEMBL28892628 | 0.65 | GAA (0.40) | RAB9ANPC1KMT2AEGFRHTR1A | |
| SCHEMBL30003246 | 0.65 | GAA (0.40) | RAB9ANPC1KMT2AEGFRHTR1A | |
| SCHEMBL1797434 | 0.65 | RPS6KA5 (0.42) | — | |
| SCHEMBL20876320 | 0.64 | NPC1 (0.54) | RAB9ANPC1KMT2AHTR1AADRA1D | |
| SCHEMBL8166660 | 0.64 | NPC1 (0.48) | RAB9ANPC1KMT2ARECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143024-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |