Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503366 | 0.83 | GRIN2D (0.39) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL6501299 | 0.76 | CA4 (0.34) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| Alcohol SCHEMBL27455943 | 0.69 | TDP1 (0.35) | SIGMAR1OPRM1RAB9AMEN1KMT2A | |
| SCHEMBL26607916 | 0.68 | AR (0.43) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL28870942 | 0.68 | — | — | |
| SCHEMBL1829382 | 0.68 | LTA4H (0.39) | LTA4HMEN1KMT2ATSHRCHRNB4 | |
| SCHEMBL1827943 | 0.68 | LTA4H (0.40) | KCNH2RAB9ALTA4HTSHRKDM4E | |
| SCHEMBL28643916 | 0.66 | CYP2D6 (0.41) | CYP2B6KCNH2SIGMAR1RAB9ALTA4H | |
| Hydrochloric Acid SCHEMBL5223635 | 0.66 | LTA4H (0.38) | LTA4HMEN1KMT2ATSHRCHRNB4 | |
| SCHEMBL1456783 | 0.66 | CYP2D6 (0.41) | CYP2B6KCNH2SIGMAR1RAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569342-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| EP-1667972-B1 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD (GB) | 2013-06-19 | — | — | EP | disclosed |
| US-7504419-B2 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER SINGH | 2009-03-17 | — | — | US | disclosed |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | BRENTWOOD EQUITIES, LTD. | 2008-11-20 | — | — | US | disclosed |
| EP-1667972-A2 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD. (GB) | 2006-06-14 | — | — | EP | disclosed |
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | RATTAN BALVINDER S (GB) | 2005-09-15 | — | — | US | disclosed |
| WO-2005023767-A2 | DIASTEREOMERS OF 4-ARYLOXY-3-HYDROXYPIPERIDINES | BRENTWOOD EQUITIES LTD. (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203136-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | GRIN1 352/4885GRIN2A 92/4885GRIN2B 184/4885 |
| US-20080287500-A1 | Diastereomers of 4-aryloxy-3-hydroxypiperidines | HTR2C, HTR4, HTR5A | GRIN1 352/4885GRIN2A 92/4885GRIN2B 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.