Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558226 | 0.83 | GRIN1 (0.37) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL8120914 | 0.70 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL10670349 | 0.67 | SIGMAR1 (0.59) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL8552014 | 0.66 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL6501299 | 0.66 | CA4 (0.34) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL1827943 | 0.65 | LTA4H (0.40) | KCNH2CYP2D6 | |
| SCHEMBL1456783 | 0.64 | CYP2D6 (0.41) | KCNH2CYP2B6SIGMAR1CYP2D6 | |
| SCHEMBL28643916 | 0.64 | CYP2D6 (0.41) | KCNH2CYP2B6SIGMAR1CYP2D6 | |
| SCHEMBL74752 | 0.64 | CYP2D6 (0.41) | KCNH2CYP2B6SIGMAR1CYP2D6 | |
| SCHEMBL27593274 | 0.63 | GRIN1 (0.46) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1576134-B1 | METHOD FOR DISCOVERING NEUROGENIC AGENTS | KELLEHER-ANDERSSON JUDITH (US) | 2013-03-06 | — | — | EP | claimed |
| US-8846914-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140147424-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8674098-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20130195816-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-8362262-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120027733-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-8058434-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-8030492-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20110135612-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-06-09 | — | — | US | disclosed |
| US-20110052552-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-03-03 | — | — | US | disclosed |
| US-7858628-B2 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100034784-A1 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-02-11 | — | — | US | disclosed |
| US-7560553-B1 | 1-(Pyrid-4-yl-methyl-),4-((6-piperazino)pyrid-5-yl)-piperazine; proliferation/differentiation of human hippocampal multipotent stem/progenitor cells and neuronal progenitors; drug screening; learning enhancement; cognition activators; Alzheimer's disease; antidepressants; brain trauma; neuroprotectants | NEURALSTEM, INC. (US) | 2009-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100034784-A1 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | DCX, MKI67, INA | GRIN2D 88/4885GRIN3B 35/4885GRIN1 32/4885 |
| US-20140147424-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | GRIN2D 83/4885GRIN3B 33/4885GRIN1 39/4885 |
| US-20110052552-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | GRIN2D 67/4885GRIN3B 35/4885GRIN1 32/4885 |
| US-20110135612-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | GRIN2D 83/4885GRIN3B 33/4885GRIN1 39/4885 |
| US-20130195816-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | GRIN2D 83/4885GRIN3B 33/4885GRIN1 39/4885 |
| US-20120027733-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | GRIN2D 83/4885GRIN3B 33/4885GRIN1 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.