Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28276628 | 0.84 | KMT2A (0.41) | TDP1KMT2ARIPK1KDM4EALDH1A1 | |
| SCHEMBL28218243 | 0.80 | TDP1 (0.44) | TDP1KMT2ARIPK1KDM4EALDH1A1 | |
| SCHEMBL4802569 | 0.78 | CHRNB2 (0.50) | TDP1KMT2ARIPK1KDM4EALDH1A1 | |
| SCHEMBL27696116 | 0.77 | AKR1C3 (0.47) | RIPK1 | |
| SCHEMBL28292504 | 0.75 | KMT2A (0.47) | TDP1KMT2ARIPK1KDM4EALDH1A1 | |
| SCHEMBL29136052 | 0.74 | KMT2A (0.46) | TDP1KMT2ARIPK1KDM4EALDH1A1 | |
| SCHEMBL2703180 | 0.73 | OPRK1 (0.43) | TDP1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL943677 | 0.73 | OPRK1 (0.43) | TDP1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL1075333 | 0.73 | OPRK1 (0.43) | TDP1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL28276595 | 0.73 | RIPK1 (0.45) | TDP1KMT2ARIPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | TDP1 795/4885KMT2A 58/4885RIPK1 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.