Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | VHL | P40337 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048657 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1VHLSCDCHRM4 | |
| SCHEMBL4030640 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1VHLSCDCHRM4 | |
| SCHEMBL4205317 | 0.82 | HSD17B13 (0.60) | SMN1; SMN2L3MBTL1CHRM4KMT2AHPGD | |
| SCHEMBL4025840 | 0.82 | CHRM4 (0.53) | SMN1; SMN2L3MBTL1CHRM4KMT2AKDM4E | |
| SCHEMBL4362487 | 0.80 | L3MBTL1 (0.54) | SMN1; SMN2L3MBTL1VHLMAPTCHRM4 | |
| SCHEMBL11536219 | 0.78 | CXCR4 (0.64) | SMN1; SMN2L3MBTL1MAPTHTTSCD | |
| SCHEMBL3369612 | 0.77 | KMT2A (0.56) | MAPTCHRM4LMNAKMT2AALDH1A1 | |
| SCHEMBL244641 | 0.77 | SCD (0.58) | SMN1; SMN2L3MBTL1MAPTHTTSCD | |
| SCHEMBL3042709 | 0.76 | CHRM4 (0.57) | SMN1; SMN2L3MBTL1MAPTHTTSCD | |
| SCHEMBL3454547 | 0.76 | SCD (0.57) | SMN1; SMN2L3MBTL1MAPTHTTSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |