Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.53 |
| ▸ | SCD | O00767 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | VHL | P40337 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559627 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1CHRM4SCDVHL | |
| SCHEMBL4025840 | 0.81 | CHRM4 (0.53) | SMN1; SMN2L3MBTL1CHRM4KMT2AMET | |
| SCHEMBL3048657 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1CHRM4SCDMMP13 | |
| SCHEMBL4205317 | 0.79 | HSD17B13 (0.60) | SMN1; SMN2L3MBTL1CHRM4MAOBKMT2A | |
| SCHEMBL243781 | 0.79 | SCD (0.61) | CHRM4SCDMMP13CXCR4MAOB | |
| SCHEMBL4362487 | 0.77 | L3MBTL1 (0.54) | SMN1; SMN2L3MBTL1CHRM4VHLKMT2A | |
| SCHEMBL5608014 | 0.76 | SCD (0.58) | SMN1; SMN2CHRM4SCDCXCR4MAOB | |
| SCHEMBL30309973 | 0.74 | KMT2A (0.51) | CHRM4SCDMMP13MAOBCACNA1G | |
| SCHEMBL26654921 | 0.73 | VHL (0.53) | MMP13VHLP2RX7 | |
| SCHEMBL21101550 | 0.73 | PKM (0.56) | SMN1; SMN2L3MBTL1VHLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | claimed |