Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | HSD17B13 | Q7Z5P4 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205317 | 0.90 | HSD17B13 (0.60) | CHRM4HSD17B13ARNR3C1MET | |
| SCHEMBL4559627 | 0.82 | SMN1; SMN2 (0.60) | CHRM4SMN1; SMN2L3MBTL1KMT2AHPGD | |
| SCHEMBL4030640 | 0.81 | SMN1; SMN2 (0.54) | CHRM4ARMETSMN1; SMN2L3MBTL1 | |
| SCHEMBL3048657 | 0.73 | SMN1; SMN2 (0.59) | CHRM4SMN1; SMN2L3MBTL1KDM4EPKM | |
| SCHEMBL3562274 | 0.73 | ALDH1A1 (0.48) | CHRM4METHTR7ROCK2ROCK1 | |
| SCHEMBL15222555 | 0.72 | CHRM4 (0.74) | CHRM4 | |
| SCHEMBL9314231 | 0.72 | GAA (0.60) | SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL21101550 | 0.72 | PKM (0.56) | SMN1; SMN2L3MBTL1KMT2AHPGDKDM4E | |
| SCHEMBL4329523 | 0.72 | CNR1 (0.45) | CHRM4METROCK2ROCK1 | |
| SCHEMBL16945275 | 0.70 | CHRM4 (0.48) | CHRM4METHTR7KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |