Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733617 | 0.99 | CLPP (0.49) | CLPPACP1GAAPTGIRMEN1 | |
| SCHEMBL4559249 | 0.92 | CLPP (0.46) | CLPPGAAMEN1KMT2AACHE | |
| SCHEMBL4561238 | 0.92 | CLPP (0.46) | CLPPACP1GAAMEN1KMT2A | |
| SCHEMBL4559247 | 0.91 | SMN1; SMN2 (0.53) | CLPPACP1GAAKMT2ABACE1 | |
| SCHEMBL2733450 | 0.91 | ALDH1A1 (0.45) | CLPPGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL2733597 | 0.89 | PIK3CA (0.46) | CLPPGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL15283501 | 0.89 | LTA4H (0.51) | CLPPMEN1KMT2AHRH3MAPT | |
| SCHEMBL2731214 | 0.87 | RAB9A (0.45) | CLPPGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL4561029 | 0.86 | ALDH1A1 (0.42) | CLPPGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL2727928 | 0.85 | ALDH1A1 (0.41) | CLPPGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632916-B1 | NOVEL ANTI-CANCER AGENTS | THE WALTER AND ELIZA HALL INST OF MEDICAL RES (AU) | 2017-01-11 | — | — | EP | disclosed |
| US-20160145243-A1 | Novel Anti-Cancer Agents | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2016-05-26 | — | — | US | disclosed |
| US-9221799-B2 | Anti-cancer agents | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2015-12-29 | — | — | US | disclosed |
| US-20150045365-A1 | Novel Anti-Cancer Agents | WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2015-02-12 | — | — | US | disclosed |
| US-8835629-B2 | Anti-cancer agents | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2014-09-16 | — | — | US | disclosed |
| US-20130261119-A1 | Novel Anti-Cancer Agents | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2013-10-03 | — | — | US | disclosed |
| WO-2012054978-A1 | NOVEL ANTI-CANCER AGENTS | LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045365-A1 | Novel Anti-Cancer Agents | TP53, SLC10A1, HDAC6 | CLPP 4788/4885ACP1 1827/4885GAA 765/4885 |
| US-20130261119-A1 | Novel Anti-Cancer Agents | TP53, SLC10A1, ARFGAP1 | CLPP 4737/4885ACP1 2180/4885GAA 1112/4885 |
| US-20160145243-A1 | Novel Anti-Cancer Agents | TP53, SLC10A1, HDAC6 | CLPP 4788/4885ACP1 1827/4885GAA 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.