SCHEMBL456035

SCHEMBL456035

Ic1[c]cccc1-c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
HSD17B10 Q99714 2/20 0.39
HPGD P15428 1/20 0.39
BCL2L1 Q07817 1/20 0.39
CYP2A6 P11509 1/20 0.39
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
BACE1 P56817 1/20 0.36
DPP4 P27487 1/20 0.35
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
BCAT2 O15382 1/20 0.33
CASP3 P42574 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
PTGS2 P35354 1/20 0.32
PARP1 P09874 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL456302 0.77
SCHEMBL185890 0.74 ALDH1A1 (0.41) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL6709412 0.74 CYP2A6 (0.41) ALDH1A1HSD17B10HPGDCYP2A6TDP1
SCHEMBL4367790 0.74 NOTUM (0.33) ALDH1A1MAPK1
SCHEMBL11687667 0.74 ALDH1A1 (0.41) ALDH1A1HSD17B10HPGDMAPK1TDP1
SCHEMBL7393282 0.73 ALDH1A1 (0.50) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL693994 0.73 ALDH1A1 (0.39) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL3978906 0.73 CYP2A6 (0.50) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL695988 0.73 PDCD1 (0.39) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6
SCHEMBL5182575 0.73 ALDH1A1 (0.50) ALDH1A1HSD17B10HPGDBCL2L1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016201288-A1 NOVEL ANTIBACTERIAL COMPOUNDS AND METHODS OF MAKING AND USING SAME BROWN UNIVERSITY (US) 2016-12-15 WO claimed
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed
US-5358966-A Using n,n'-diacylhydrazine ROHM AND HAAS COMPANY (US) 1994-10-25 US disclosed