Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561508 | 0.87 | POLB (0.56) | POLBKLK7ALDH1A1GAAL3MBTL1 | |
| SCHEMBL8084866 | 0.82 | PPARA (0.47) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17724542 | 0.82 | PPARA (0.47) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9256009 | 0.81 | HDAC2 (0.54) | HDAC2POLBKLK7ALDH1A1GAA | |
| SCHEMBL16673029 | 0.81 | KMT2A (0.53) | ALDH1A1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL23829508 | 0.80 | ALDH1A1 (0.45) | POLBALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL16672826 | 0.79 | LMNA (0.51) | ALDH1A1GAAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL20538944 | 0.79 | LMNA (0.43) | POLBALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8049390 | 0.78 | ALDH1A1 (0.77) | POLBKLK7ALDH1A1GAAL3MBTL1 | |
| SCHEMBL16672581 | 0.78 | MMP8 (0.50) | POLBALDH1A1GAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | HDAC2 5/4885POLB 425/4885KLK7 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.