Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305951 | 0.89 | AKR1C2 (0.49) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL8796396 | 0.86 | TRPV1 (0.46) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL11021014 | 0.83 | TRPV1 (0.46) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL8594951 | 0.79 | TRPV1 (0.42) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL8978361 | 0.79 | TRPV1 (0.42) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL8978296 | 0.78 | PDGFRB (0.42) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL8669584 | 0.78 | AKR1C2 (0.44) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL25260242 | 0.77 | ALDH1A1 (0.58) | AKR1C2PDGFRBFGFR1KDRALDH1A1 | |
| SCHEMBL10637946 | 0.77 | PIKFYVE (0.42) | AKR1C2TRPV1PDGFRBFGFR1KDR | |
| SCHEMBL5270294 | 0.77 | AKR1C2 (0.58) | AKR1C2TRPV1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722434-A1 | NITRIC ESTERS HAVING ANTI-INFLAMMATORY AND/OR ANALGESIC ACTIVITY AND PROCESS FOR THEIR PREPARATION | NICOX S.A. (FR) | 1996-07-24 | — | — | EP | claimed |
| EP-0006223-A1 | Crystalline sodium and potassium indomethacin and their trihydrates, process for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1980-01-09 | — | — | EP | claimed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| EP-1131326-A4 | PHOSPHOLIPID DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | DPHARM LTD (IL) | 2002-03-27 | — | — | EP | disclosed |
| EP-1131326-A1 | PHOSPHOLIPID DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | D-Pharm Limited (IL) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031083-A1 | PHOSPHOLIPID DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | D-PHARM LIMITED (IL) | 2000-06-02 | — | — | WO | disclosed |
| EP-0723442-A4 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS INC (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0723442-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0722434-A1 | NITRIC ESTERS HAVING ANTI-INFLAMMATORY AND/OR ANALGESIC ACTIVITY AND PROCESS FOR THEIR PREPARATION | NICOX S.A. (FR) | 1996-07-24 | — | — | EP | disclosed |
| WO-1996003987-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-02-15 | — | — | WO | disclosed |