Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562595 | 0.86 | AKR1C2 (0.48) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL5305951 | 0.86 | AKR1C2 (0.49) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8578419 | 0.81 | TRPV1 (0.51) | TRPV1AKR1C2PIKFYVEALDH1A1MEN1 | |
| SCHEMBL11021014 | 0.79 | TRPV1 (0.46) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8686345 | 0.78 | TRPV1 (0.50) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8978325 | 0.78 | TRPV1 (0.42) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8978361 | 0.77 | TRPV1 (0.42) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8978296 | 0.76 | PDGFRB (0.42) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL10637946 | 0.75 | PIKFYVE (0.42) | TRPV1PDGFRBFGFR1KDRAKR1C2 | |
| SCHEMBL8594951 | 0.75 | TRPV1 (0.42) | TRPV1PDGFRBFGFR1KDRAKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723442-A4 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS INC (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0723442-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1996003987-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-02-15 | — | — | WO | disclosed |