SCHEMBL456272

SCHEMBL456272

CC(=O)CC(=O)c1ccc(C[C@H](N)C(=O)O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 6/20 0.59
TPH1 P17752 3/20 0.58
PTGS1 P23219 3/20 0.58
ALPI P09923 1/20 0.58
PKM P14618 1/20 0.58
XIAP P98170 1/20 0.58
PTPRC P08575 1/20 0.51
HIF1A Q16665 4/20 0.50
ALOX15 P16050 3/20 0.50
KDM4E B2RXH2 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
GRB2 P62993 1/20 0.50
USP2 O75604 1/20 0.50
EGFR P00533 1/20 0.50
LCK P06239 1/20 0.50
FYN P06241 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
HTR2A P28223 1/20 0.50
PTGS2 P35354 1/20 0.50
RECQL P46063 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL456271 1.00 SLC7A5 (0.59) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL14036368 0.87 TPH1 (0.44) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL27759375 0.86 SLC7A5 (0.62) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL384961 0.86 SLC7A5 (0.62) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL12028774 0.86 SLC7A5 (0.54) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL8229295 0.86 SLC7A5 (0.54) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL8237014 0.86 SLC7A5 (0.56) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL12142792 0.86 SLC7A5 (0.54) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL12142783 0.85 SLC7A5 (0.57) SLC7A5TPH1PTGS1ALPIPKM
SCHEMBL12641443 0.85 SLC7A5 (0.61) SLC7A5TPH1PTGS1ALPIPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 540 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4644570-A1 HELICASE MUTANT, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN HIGH-THROUGHPUT SEQUENCING BGI Shenzhen (CN) 2025-11-05 EP claimed
US-20250243472-A1 MODIFIED HELICASES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-07-31 US claimed
WO-2024138632-A1 HELICASE, PREPARATION METHOD THEREFOR AND USE THEREOF IN SEQUENCING 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138422-A1 PIN DOMAIN, HELICASE CONTAINING SAME, PREPARATION METHOD FOR PIN DOMAIN, AND USE OF PIN DOMAIN 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138626-A1 HELICASE TOPIF 1, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN HIGH-THROUGHPUT SEQUENCING 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138701-A1 HELICASE MUTANT, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN HIGH-THROUGHPUT SEQUENCING 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138635-A1 HELICASE AND PREPARATION METHOD THEREFOR AND USE THEREOF IN HIGH-THROUGHPUT SEQUENCING 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138574-A1 HELICASE AND USE THEREOF 深圳华大生命科学研究院 2024-07-04 WO claimed
WO-2024138380-A1 HELICASE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN HIGH-THROUGHPUT SEQUENCING 青岛华大基因研究院 2024-07-04 WO claimed
CN-118256603-A Modified enzymes 牛津纳米孔科技公开有限公司 2024-06-28 CN claimed
US-20080233611-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids THE SCRIPPS RESEARCH INSTITUTE (US) 2008-09-25 US claimed
US-20080171317-A1 Site-Specific Labeling of Proteins for Nmr Studies THE SCRIPPS RESEARCH INSTITUTE (US) 2008-07-17 US claimed
EP-1807515-A4 ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS SCRIPPS RESEARCH INST (US) 2008-06-18 EP claimed
CN-101048506-A Orthogonal translation Components for in vivo incorporation of unnatural amino acids SCRIPPS RESEARCH INST (US) 2007-10-03 CN claimed
US-20070178448-A1 Selective posttranslational modification of phage-displayed polypeptides THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-02 US claimed
EP-1807515-A2 ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS The Scripps Research Institute (US) 2007-07-18 EP claimed
EP-1794312-A2 SITE-SPECIFIC LABELING OF PROTEINS FOR NMR STUDIES The Scripps Research Institute (US) 2007-06-13 EP claimed
WO-2006110182-A2 ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2006-10-19 WO claimed
US-20060110784-A1 Site-specific labeling of proteins for NMR studies THE SCRIPPS RESEARCH INSTITUTE (US) 2006-05-25 US claimed
WO-2006036779-A2 SITE-SPECIFIC LABELING OF PROTEINS FOR NMR STUDIES THE SCRIPPS RESEARCH INSTITUTE (US) 2006-04-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080233611-A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids AARS1, NSUN3, OSGEP SLC7A5 360/4885TPH1 2835/4885PTGS1 3372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.