Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | CCR6 | P51684 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.55 |
| ▸ | APLNR | P35414 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.54 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916024 | 0.86 | PAX8 (0.68) | NPC1RAB9ASMN1; SMN2CCR6TP53 | |
| SCHEMBL12706320 | 0.86 | PAX8 (0.68) | NPC1RAB9ASMN1; SMN2CCR6TP53 | |
| SCHEMBL20101097 | 0.84 | CCR6 (0.68) | NPC1RAB9ASMN1; SMN2CCR6TP53 | |
| SCHEMBL11332741 | 0.78 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2CCR6TP53 | |
| SCHEMBL18693004 | 0.73 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL28476553 | 0.71 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2NCF1KMT2A | |
| SCHEMBL6257291 | 0.71 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL14075818 | 0.71 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2CCR6TP53 | |
| SCHEMBL15267189 | 0.70 | KDM4E (0.58) | NPC1RAB9ASMN1; SMN2TP53CYP1A2 | |
| SCHEMBL1133878 | 0.70 | NCF1 (0.65) | NPC1RAB9ASMN1; SMN2CCR6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073811-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008046003-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-04-17 | — | — | WO | disclosed |