Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915150 | 0.83 | MAPT (0.42) | XDHNTRK1MAP2K1AURKBALDH1A1 | |
| SCHEMBL4563321 | 0.82 | DHFR (0.54) | LRRK2ADORA1ADORA2ACHEK1MAP4K4 | |
| SCHEMBL4562986 | 0.82 | MAP4K4 (0.47) | LRRK2CDK9MAP4K4PIM1PRKACA | |
| SCHEMBL3485241 | 0.80 | PARP1 (0.47) | XDHLRRK2MAP4K4CSF1RFGFR1 | |
| SCHEMBL4563212 | 0.78 | XDH (0.54) | XDHADORA1ADORA2ACDK9PIM1 | |
| SCHEMBL11743569 | 0.76 | LRRK2 (0.49) | XDHLRRK2RAB9AADORA1ADORA2A | |
| SCHEMBL4563179 | 0.75 | XDH (0.57) | XDHADORA1ADORA2APIM1TYRO3 | |
| SCHEMBL2349960 | 0.71 | XDH (0.53) | XDHRAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL8107168 | 0.71 | LRRK2 (0.62) | LRRK2CDK9MAP4K4ABL1NTRK1 | |
| SCHEMBL13680655 | 0.70 | LYN (0.57) | XDHRAB9ACDK9FYNCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | YALE UNIVERISTY (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | CHRNA1, CHRNA5, CHRNA10 | XDH 372/4885LRRK2 2996/4885RAB9A 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.