Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.62 |
| ▸ | STK4 | Q13043 | 3/20 | 0.62 |
| ▸ | STK3 | Q13188 | 3/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353306 | 0.83 | LRRK2 (0.62) | LRRK2STK4STK3JAK3MAP4K4 | |
| SCHEMBL12438584 | 0.83 | LRRK2 (0.55) | LRRK2STK4STK3PIK3CDPIK3CA | |
| SCHEMBL4350720 | 0.83 | STK4 (0.68) | LRRK2STK4STK3MAP4K4SRC | |
| SCHEMBL8114068 | 0.83 | ADK (0.49) | LRRK2STK4STK3 | |
| SCHEMBL7013879 | 0.82 | LRRK2 (0.65) | LRRK2STK4STK3PIK3CDPIK3CA | |
| SCHEMBL1896766 | 0.82 | STK3 (0.58) | LRRK2STK4STK3PIK3CDPIK3CA | |
| SCHEMBL7021288 | 0.82 | LRRK2 (0.63) | LRRK2STK4STK3PIK3CDPIK3CA | |
| SCHEMBL8112985 | 0.80 | CCNT1 (0.48) | LRRK2STK4STK3PIK3CDPIK3CA | |
| SCHEMBL19226297 | 0.78 | KDR (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL6639433 | 0.78 | LRRK2 (0.81) | LRRK2STK4STK3CDK8MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |