Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 2/20 | 0.35 |
| ▸ | CPT1A | P50416 | 2/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 3/20 | 0.34 |
| ▸ | EDNRA | P25101 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995411 | 0.90 | MCOLN3 (0.37) | MCOLN3HCRTR1HCRTR2FABP4EPHX2 | |
| SCHEMBL1998005 | 0.84 | TSHR (0.39) | HCRTR1HCRTR2PPARGPPARDPPARA | |
| SCHEMBL1997844 | 0.81 | MCOLN3 (0.40) | MCOLN3HCRTR1HCRTR2FABP4PPARG | |
| SCHEMBL1999661 | 0.80 | HTR6 (0.46) | — | |
| SCHEMBL4418508 | 0.76 | ALDH1A1 (0.39) | FABP4ALDH1A1POLBKMT2AMAPK1 | |
| SCHEMBL1997467 | 0.75 | ALDH1A1 (0.38) | PPARGPPARDPPARAALDH1A1KMT2A | |
| SCHEMBL1995995 | 0.74 | HTR6 (0.36) | — | |
| SCHEMBL4418093 | 0.74 | FABP4 (0.40) | FABP4CPT2CPT1ACPT1BTSHR | |
| SCHEMBL1995069 | 0.74 | TSHR (0.42) | ALDH1A1CPT2CPT1ACPT1BKMT2A | |
| SCHEMBL1996187 | 0.73 | FABP4 (0.39) | FABP4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |