SCHEMBL456344

SCHEMBL456344

NC(=S)NN=C1Nc2ccccc2C1=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.50
MEN1 O00255 4/20 0.50
GAA P10253 2/20 0.50
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
ALDH1A1 P00352 4/20 0.40
MAPT P10636 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
LMNA P02545 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HTT P42858 2/20 0.36
HPGD P15428 1/20 0.36
PDGFRA P16234 1/20 0.36
FER P16591 1/20 0.36
LTK P29376 1/20 0.36
CDK8 P49336 1/20 0.36
ACVR1 Q04771 1/20 0.36
LRRK2 Q5S007 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3063202 0.83 KMT2A (0.60) KMT2AMEN1GAAALDH1A1MAPT
SCHEMBL457313 0.79 TDP1 (0.56) KMT2AMEN1GAAMAOAMAOB
SCHEMBL10084821 0.79 KMT2A (0.58) KMT2AMEN1GAAALDH1A1MAPT
SCHEMBL98437 0.79 KMT2A (0.58) KMT2AMEN1GAAALDH1A1MAPT
SCHEMBL3076655 0.79 KMT2A (0.61) KMT2AMEN1GAAMAOBALDH1A1
SCHEMBL11237095 0.78 KMT2A (0.53) KMT2AMEN1GAAALDH1A1LMNA
SCHEMBL11237090 0.78 KMT2A (0.53) KMT2AMEN1GAAALDH1A1LMNA
SCHEMBL19586520 0.78 KMT2A (0.57) KMT2AMEN1GAAALDH1A1MAPT
SCHEMBL458246 0.77 ALDH1A1 (0.49) KMT2AMEN1GAAMAOAMAOB
SCHEMBL2877863 0.76 ALDH1A1 (0.46) KMT2AMEN1GAAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070015815-A1 Hydrazide substrate shuts down protein biosynthesis capability in cells that host a metastatic or malignant disease mechanism DELOACH REUBEN E 2007-01-18 US claimed
EP-0661967-B1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS UNIV VIRGINIA (US) 1999-08-25 EP claimed
EP-0661967-A1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS CENTER FOR INNOVATIVE TECHNOLOGY (US) 1995-07-12 EP claimed
US-5422097-A Combined antiviral and antimediator treatment of common colds UNIVERSITY OF VIRGINIA (US) 1995-06-06 US claimed
EP-0661967-A4 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS. UNIV VIRGINIA (US) 1994-09-29 EP claimed
US-5240694-A Combined antiviral and antimediator treatment of common colds UNIVERSITY OF VIRGINIA (US) 1993-08-31 US claimed
WO-1993009764-A1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS CENTER FOR INNOVATIVE TECHNOLOGY (US) 1993-05-27 WO claimed
US-12419947-B2 Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production NAJIT TECHNOLOGIES, INC. (US) 2025-09-23 US disclosed
US-12102676-B2 Inactivating pathogens and producing highly immunogenic inactivated vaccines using a dual oxidation process NAJIT TECHNOLOGIES, INC. (US) 2024-10-01 US disclosed
US-20240269257-A1 INORGANIC POLYATOMIC OXYANIONS FOR PROTECTING AGAINST ANTIGENIC DAMAGE DURING PATHOGEN INACTIVATION FOR VACCINE PRODUCTION Najít Technologies, Inc. 2024-08-15 US disclosed
EP-3454895-B1 INORGANIC POLYATOMIC OXYANIONS FOR PROTECTING AGAINST ANTIGENIC DAMAGE DURING PATHOGEN INACTIVATION FOR VACCINE PRODUCTION NAJIT TECH INC (US) 2024-03-27 EP disclosed
US-11844832-B2 Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production NAJIT TECHNOLOGIES, INC. (US) 2023-12-19 US disclosed
US-20230346910-A1 INACTIVATING PATHOGENS AND PRODUCING HIGHLY IMMUNOGENIC INACTIVATED VACCINES USING A DUAL OXIDATION PROCESS Najít Technologies, Inc. 2023-11-02 US disclosed
US-5422097-A Combined antiviral and antimediator treatment of common colds UNIVERSITY OF VIRGINIA (US) 1995-06-06 US disclosed
WO-1994027436-A1 PRESERVATIVE SYSTEMS WITH ENHANCED ANTIMICROBIAL ACTIVITY DECICCO BENEDICT T (US) 1994-12-08 WO disclosed
EP-0661967-A4 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS. UNIV VIRGINIA (US) 1994-09-29 EP disclosed
US-5240694-A Combined antiviral and antimediator treatment of common colds UNIVERSITY OF VIRGINIA (US) 1993-08-31 US disclosed
WO-1993009764-A1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS CENTER FOR INNOVATIVE TECHNOLOGY (US) 1993-05-27 WO disclosed
US-4780477-A Isatin compositions having anti-ulcer activities KISSEI PHARMACEUTICAL CO., LTD. (JP) 1988-10-25 US disclosed
EP-0205299-A2 Isatin derivatives, compositions containing the same, and the use thereof for ulcer diseases Kissei Pharmaceutical Co. Ltd. (JP) 1986-12-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240269257-A1 INORGANIC POLYATOMIC OXYANIONS FOR PROTECTING AGAINST ANTIGENIC DAMAGE DURING PATHOGEN INACTIVATION FOR VACCINE PRODUCTION OGG1, EIF2AK2, AS3MT KMT2A 1141/4885MEN1 3572/4885GAA 417/4885
US-20230346910-A1 INACTIVATING PATHOGENS AND PRODUCING HIGHLY IMMUNOGENIC INACTIVATED VACCINES USING A DUAL OXIDATION PROCESS DUOX2, DUOX1, TET2 KMT2A 1061/4885MEN1 2602/4885GAA 1798/4885
US-12419947-B2 Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production OGG1, EIF2AK2, AS3MT KMT2A 1141/4885MEN1 3572/4885GAA 417/4885
US-11844832-B2 Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production OGG1, EIF2AK2, AS3MT KMT2A 1141/4885MEN1 3572/4885GAA 417/4885
US-12102676-B2 Inactivating pathogens and producing highly immunogenic inactivated vaccines using a dual oxidation process DUOX2, DUOX1, TET2 KMT2A 1061/4885MEN1 2602/4885GAA 1798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.