Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564307 | 0.77 | NPC1 (0.42) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL9397982 | 0.75 | CYP3A4 (0.43) | NPC1ALDH1A1KMT2AGAAPOLB | |
| SCHEMBL5638922 | 0.72 | NPC1 (0.49) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28330184 | 0.72 | PI4KA (0.49) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL9405397 | 0.72 | NPC1 (0.49) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28367072 | 0.72 | NPC1 (0.45) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL27659057 | 0.70 | P2RX4 (0.46) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL4866386 | 0.70 | NPC1 (0.46) | NPC1MAPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL11345662 | 0.69 | TDP1 (0.42) | HCAR1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL27944468 | 0.69 | NPC1 (0.45) | NPC1MAPK1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061464-A2 | COMBINATION THERAPY FOR TUMORAL DISEASE TREATMENT | Ramot, at Tel Aviv University Ltd. (IL) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008032324-A2 | COMBINATION THERAPY FOR TUMORAL DISEASE TREATMENT | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-03-20 | — | — | WO | disclosed |