Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29362699 | 0.85 | IKBKB (0.46) | IKBKBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL668702 | 0.84 | ALDH1A1 (0.47) | IKBKBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL1018417 | 0.82 | KDM4E (0.44) | IKBKBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4735612 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL28203375 | 0.79 | KDM4E (0.44) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL334956 | 0.78 | KMT2A (0.47) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL30177551 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL9875978 | 0.77 | G6PD (0.51) | IKBKBALDH1A1KDM4EMAPTHPGD | |
| Hydrochloric Acid SCHEMBL7763898 | 0.77 | KMT2A (0.46) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL363595 | 0.76 | BCAT2 (0.48) | ALDH1A1KDM4EMAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121637-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | Smithkline Beecham Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008092049-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-31 | — | — | WO | disclosed |