Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440949 | 0.79 | ALDH1A1 (0.37) | KDM4ESMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL391774 | 0.75 | ALDH1A1 (0.37) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14507079 | 0.75 | KMT2A (0.58) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL17279782 | 0.73 | NPC1 (0.44) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6316045 | 0.71 | TSHR (0.58) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2662447 | 0.71 | HSD11B1 (0.46) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8612344 | 0.70 | TAAR1 (0.53) | SMN1; SMN2LMNATAAR1EGFRALDH1A1 | |
| SCHEMBL10612608 | 0.70 | NPC1 (0.33) | KDM4ESMN1; SMN2RAB9ANPC1TAAR1 | |
| SCHEMBL13860567 | 0.70 | KDM4E (0.47) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14856665 | 0.70 | TAAR1 (0.53) | KDM4EKMT2ASMN1; SMN2LMNATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |