Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564843 | 0.87 | CAMK2D (0.54) | CAMK2DGSK3BKDRFLT3CCNT1 | |
| SCHEMBL4559546 | 0.81 | CAMK2D (0.41) | CAMK2DGSK3BCCNT1CDK9SIRT2 | |
| SCHEMBL4565064 | 0.78 | KDR (0.43) | CAMK2DGSK3BKDRFLT3CCNT1 | |
| SCHEMBL28661599 | 0.74 | CCNT1 (0.64) | CAMK2DGSK3BKDRFLT3CCNT1 | |
| SCHEMBL28659415 | 0.69 | GSK3B (0.66) | CAMK2DGSK3BKDRFLT3CDK2 | |
| SCHEMBL14522482 | 0.69 | GSK3B (0.69) | CAMK2DGSK3BKDRFLT3CCNT1 | |
| SCHEMBL3155154 | 0.68 | CCNT1 (0.58) | CAMK2DCCNT1CDK9CDK2CCNA2 | |
| SCHEMBL13166904 | 0.68 | CAMK2D (0.78) | CAMK2DGSK3BKDRFLT3CDK4 | |
| SCHEMBL8161322 | 0.67 | CCNE2 (0.74) | CAMK2DGSK3BCCNT1CDK9SIRT2 | |
| SCHEMBL19996601 | 0.67 | CNR2 (0.51) | CAMK2DASH1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608634-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-27 | — | — | US | disclosed |
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | ZHANG HAN-CHENG | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | CAMK2D 66/4885GSK3B 880/4885KDR 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.