Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 3/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.37 |
| ▸ | CDK9 | P50750 | 7/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565062 | 0.81 | CAMK2D (0.53) | CAMK2DGSK3BPRKCAPRKCBCCNT1 | |
| SCHEMBL4559556 | 0.79 | GSK3B (0.38) | CAMK2DGSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL4564843 | 0.77 | CAMK2D (0.54) | CAMK2DGSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL4676750 | 0.65 | GSK3B (0.50) | CAMK2DGSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL4565064 | 0.63 | KDR (0.43) | CAMK2DGSK3BPRKCAPRKCBCCNT1 | |
| SCHEMBL6949072 | 0.63 | GSK3B (0.68) | CAMK2DGSK3BCCNT1CDK9SIRT2 | |
| SCHEMBL29349877 | 0.63 | GSK3B (0.68) | CAMK2DGSK3BCCNT1CDK9SIRT2 | |
| SCHEMBL2946233 | 0.62 | PRKCA (0.51) | CAMK2DGSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL1063235 | 0.59 | GSK3B (0.61) | GSK3BPRKCACCNT1CDK9CDK2 | |
| SCHEMBL9572022 | 0.58 | GSK3B (0.64) | GSK3BPRKCACCNT1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608634-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-27 | — | — | US | disclosed |
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | ZHANG HAN-CHENG | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | CAMK2D 66/4885GSK3B 880/4885PRKCA 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.