Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 6/20 | 0.38 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983000 | 0.82 | THRA (0.47) | KDM4EPPARGPPARDPPARACHRM1 | |
| SCHEMBL13576220 | 0.75 | THRA (0.47) | KDM4ECHRM1APEX1GRIN1GRIN2B | |
| SCHEMBL3982070 | 0.64 | THRA (0.49) | KDM4ECHRM1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL3982935 | 0.62 | THRA (0.54) | ALDH1A1 | |
| SCHEMBL11192254 | 0.60 | AKR1C2 (0.52) | KDM4EGRIN1GRIN2BALDH1A1MAPT | |
| SCHEMBL11217654 | 0.59 | PRKAG1 (0.69) | KDM4EPPARGCHRM1PRKAG1PRKAA2 | |
| SCHEMBL6473944 | 0.59 | APEX1 (0.79) | KDM4ECHRM1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL14930220 | 0.59 | MAPT (0.52) | KDM4ECHRM1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL9754854 | 0.59 | KDM4E (0.45) | KDM4ECHRM1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL16176662 | 0.59 | THRB (0.60) | KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |