SCHEMBL456551

SCHEMBL456551

Sc1c(-c2ccccc2)cc(-c2ccccc2)cc1-c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
BACE1 P56817 1/20 0.46
PTPN1 P18031 1/20 0.45
HTT P42858 5/20 0.40
RAB9A P51151 3/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
NPC1 O15118 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
HPRT1 P00492 1/20 0.40
PTGS1 P23219 1/20 0.40
APAF1 O14727 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
XBP1 P17861 1/20 0.40
PTBP1 P26599 1/20 0.40
GALK1 P51570 1/20 0.40
BLM P54132 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27928636 0.97 ALDH1A1 (0.45) ALDH1A1BACE1PTPN1HTTRAB9A
Potassium SCHEMBL29843830 0.97 ALDH1A1 (0.45) ALDH1A1BACE1PTPN1HTTRAB9A
SCHEMBL22562334 0.87 MEN1 (0.41) ALDH1A1BACE1PTPN1HTTRAB9A
SCHEMBL24282836 0.85 HTT (0.44) ALDH1A1BACE1PTPN1HTTRAB9A
SCHEMBL25971265 0.84 AKR1C2 (0.42) ALDH1A1BACE1PTPN1HTTRAB9A
SCHEMBL7900444 0.80 METAP2 (0.46) ALDH1A1BACE1SMN1; SMN2HPRT1LMNA
SCHEMBL26974273 0.80 METAP2 (0.46) ALDH1A1BACE1HTTMEN1KMT2A
SCHEMBL8720645 0.80 ALDH1A1 (0.55) ALDH1A1BACE1MEN1KMT2AMAPT
SCHEMBL3183499 0.78 ALDH1A1 (0.48) ALDH1A1BACE1RAB9AMEN1KMT2A
SCHEMBL8928083 0.76 ALDH1A1 (0.50) ALDH1A1BACE1PTPN1HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108250341-B Catalyst system containing metallocene compound and method for catalyzing olefin polymerization by using catalyst system 北京引发科技有限公司 2020-12-11 CN claimed
CN-108156812-B Improved olefin metathesis catalysts 卑尔根技术交易股份公司 2022-09-30 CN disclosed
CN-109794292-B Z-selective ruthenium carbene olefin metathesis catalyst, and preparation method and application thereof 天津大学 2021-12-07 CN disclosed
CN-108250341-B Catalyst system containing metallocene compound and method for catalyzing olefin polymerization by using catalyst system 北京引发科技有限公司 2020-12-11 CN disclosed
US-10265691-B2 Olefin metathesis catalysts BERGEN TEKNOLOGIOVERFORING AS (NO) 2019-04-23 US disclosed
US-20180200704-A1 IMPROVED OLEFIN METATHESIS CATALYSTS BERGEN TEKNOLOGIOVERFORING AS (NO) 2018-07-19 US disclosed
CN-108156812-A Improved olefin metathesis catalyst 卑尔根技术交易股份公司 2018-06-12 CN disclosed
EP-3319973-A1 IMPROVED OLEFIN METATHESIS CATALYSTS Bergen Teknologioverforing AS (NO) 2018-05-16 EP disclosed
US-9795953-B2 Organometallic catalysts BERGEN TEKNOLOGIOVERFORING AS (NO) 2017-10-24 US disclosed
US-9795953-B2 Organometallic catalysts BERGEN TEKNOLOGIOVERFORING AS (NO) 2017-10-24 US disclosed
US-20030004285-A1 Procatalysts, catalyst systems, and use in olefin polymerization WESTLAKE LONGVIEW CORPORATION 2003-01-02 US disclosed
US-6465383-B2 COORDINATION CATALYST EASTMAN CHEMICAL COMPANY 2002-10-15 US disclosed
US-20010051587-A1 Procatalysts, catalyst systems, and use in olefin polymerization WESTLAKE LONGVIEW CORPORATION 2001-12-13 US disclosed
US-20010031841-A1 Procatalysts, catalyst systems, and use in olefin polymerization WESTLAKE LONGVIEW CORPORATION 2001-10-18 US disclosed
US-20010029286-A1 Procatalysts, catalyst systems, and use in OLEFIN polymerization EASTMAN CHEMICAL COMPANY, A CORP. OF DELAWARE 2001-10-11 US disclosed
US-20010025005-A1 Procatalysts, catalyst systems, and use in olefin polymerization EASTMAN CHEMICAL COMPANY, A CORPORATION OF DELAWARE 2001-09-27 US disclosed
WO-2001051526-A1 PROCATALYSTS COMPRISING BIDENTATE LIGANDS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION EASTMAN CHEMICAL COMPANY (US) 2001-07-19 WO disclosed
WO-2001051527-A1 PROCATALYSTS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION EASTMAN CHEMICAL COMPANY (US) 2001-07-19 WO disclosed
WO-2001051529-A1 PROCATALYSTS COMPRISING BIDENTATE LIGANDS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION EASTMAN CHEMICAL COMPANY (US) 2001-07-19 WO disclosed
WO-2001051528-A1 PROCATALYSTS COMPRISING BIDENTATE LIGANDS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION EASTMAN CHEMICAL COMPANY (US) 2001-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180200704-A1 IMPROVED OLEFIN METATHESIS CATALYSTS SQLE, COASY, MOGAT2 ALDH1A1 932/4885BACE1 1457/4885PTPN1 4779/4885
US-10265691-B2 Olefin metathesis catalysts SQLE, COASY, APEX1 ALDH1A1 809/4885BACE1 1678/4885PTPN1 4739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.