Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751920 | 0.84 | MEN1 (0.51) | NPBWR1MEN1POLBRAB9ABLM | |
| SCHEMBL27772593 | 0.80 | NR2E3 (0.44) | NPBWR1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL4253480 | 0.79 | ALDH1A1 (0.40) | NPBWR1MEN1POLBRAB9ABLM | |
| SCHEMBL8224521 | 0.79 | NPBWR1 (0.35) | NPBWR1MEN1POLBRAB9ABLM | |
| SCHEMBL27751740 | 0.72 | CYP2C19 (0.44) | NPBWR1MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL27751967 | 0.72 | MEN1 (0.43) | MEN1POLBKMT2ANPSR1 | |
| SCHEMBL13608157 | 0.70 | CASP3 (0.39) | — | |
| SCHEMBL4254526 | 0.70 | CASP3 (0.39) | — | |
| SCHEMBL4260200 | 0.69 | NPBWR1 (0.48) | NPBWR1MEN1POLBKMT2ANPSR1 | |
| SCHEMBL4255996 | 0.69 | CACNA1B (0.35) | NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | disclosed |
| EP-2046757-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG Life Sciences Ltd. (KR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008016239-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2008-02-07 | — | — | WO | disclosed |