Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160349 | 0.78 | NOTUM (0.44) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL7160356 | 0.78 | NOTUM (0.44) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL6143494 | 0.75 | ALDH1A1 (0.61) | MEN1KMT2ADYRK1ADYRK1BDYRK2 | |
| SCHEMBL6142893 | 0.75 | ALDH1A1 (0.61) | MEN1KMT2ADYRK1ADYRK1BDYRK2 | |
| SCHEMBL624686 | 0.74 | MEN1 (0.40) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL29960518 | 0.74 | MEN1 (0.40) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL624687 | 0.74 | MEN1 (0.40) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL9772944 | 0.72 | ESR1 (0.44) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL1452523 | 0.72 | ESR1 (0.44) | MEN1KMT2AITGB2ICAM1ITGAL | |
| SCHEMBL8085340 | 0.72 | MAOB (0.62) | MEN1KMT2ALMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534801-B2 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-20050107431-A1 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-05-19 | — | — | US | disclosed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107431-A1 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, TPH1 | MEN1 2756/4885KMT2A 2759/4885ITGB2 3965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.