Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12435378 | 0.98 | ATM (0.65) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL21568856 | 0.91 | L3MBTL1 (0.61) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL20693526 | 0.88 | ATM (0.56) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL12446607 | 0.88 | ATM (0.56) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL13188548 | 0.86 | ATM (0.58) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL18909475 | 0.82 | ATM (0.52) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL13974287 | 0.81 | GNAI3 (0.44) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL13220569 | 0.81 | ATM (0.59) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL19574089 | 0.81 | ATM (0.95) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL28366947 | 0.81 | ATM (0.85) | ATMKMT2AMEN1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132174-A1 | META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS | The Medicines Company (Leipzig) GmbH (DE) | 2009-12-16 | — | — | EP | claimed |
| WO-2008107176-A1 | META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2008-09-12 | — | — | WO | claimed |