Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123105 | 0.95 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL12352492 | 0.89 | TPSAB1 (0.41) | GNAI3GNAO1GNAI1ATMITGB3 | |
| SCHEMBL12435378 | 0.83 | ATM (0.65) | ATML3MBTL1NPC1MEN1KMT2A | |
| SCHEMBL4566692 | 0.81 | ATM (0.63) | ATML3MBTL1NPC1MEN1KMT2A | |
| SCHEMBL16756662 | 0.81 | GNAI3 (0.56) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL10337915 | 0.81 | GNAI3 (0.56) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL9415769 | 0.81 | GNAI3 (0.56) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL9415827 | 0.81 | GNAI3 (0.56) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL2998705 | 0.79 | L3MBTL1 (0.60) | GNAI3GNAO1GNAI1ATML3MBTL1 | |
| SCHEMBL20904110 | 0.78 | ATM (0.52) | GNAI3GNAO1GNAI1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| CN-113195497-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2021-07-30 | — | — | CN | disclosed |
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2012158784-A2 | MODULATORS OF THE NUCLEAR HORMONE RECEPTOR ROR | KAMENECKA THEODORE MARK (US) | 2012-11-22 | — | — | WO | disclosed |