Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804255 | 0.77 | KDM4C (0.40) | KDM4CCDK5CDK5R1KDRHSP90AA1 | |
| SCHEMBL29529148 | 0.75 | KDM4E (0.54) | KDM4CCDK5CDK5R1KDRHSP90AA1 | |
| SCHEMBL439769 | 0.75 | KDM4E (0.54) | KDM4CCDK5CDK5R1KDRHSP90AA1 | |
| SCHEMBL17850816 | 0.74 | — | — | |
| SCHEMBL27768754 | 0.73 | KDM4E (0.52) | KDM4CCDK5CDK5R1KDRHSP90AA1 | |
| Pyridine SCHEMBL28181012 | 0.73 | KDM4C (0.49) | KDM4CCDK5CDK5R1KDRHSP90AA1 | |
| SCHEMBL2814353 | 0.72 | HSP90AA1 (0.52) | CDK5CDK5R1CCNT1CCNA2CDK2 | |
| SCHEMBL30595872 | 0.72 | HSP90AA1 (0.52) | CDK5CDK5R1CCNT1CCNA2CDK2 | |
| SCHEMBL6577254 | 0.72 | CYP3A4 (0.44) | CDK5CDK5R1CCNT1CCNA2CDK2 | |
| SCHEMBL1904338 | 0.72 | KDM4C (0.47) | KDM4CCDK5CDK5R1KDRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252163-B1 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2003-09-24 | — | — | EP | claimed |
| WO-2020254697-A1 | FUSED 1,2 THIAZOLES AND 1,2 THIAZINES WHICH ACT AS NL3P3 MODULATORS | AC IMMUNE SA (CH) | 2020-12-24 | — | — | WO | disclosed |
| US-8426417-B2 | Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-04-23 | — | — | US | disclosed |
| US-8426417-B2 | Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-04-23 | — | — | US | disclosed |
| US-20120122882-A1 | Substituted Pyrrolo-Pyrimidine Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-05-17 | — | — | US | disclosed |
| US-20120122882-A1 | Substituted Pyrrolo-Pyrimidine Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-05-17 | — | — | US | disclosed |
| WO-2005019207-A1 | FUNGICIDAL PYRIMIDINE DERIVATIVES | NIPPON SODA CO. LTD. (JP) | 2005-03-03 | — | — | WO | disclosed |
| US-20050038041-A1 | Fungicidal pyrimidine derivatives | NIPPON SODA CO., LTD. (JP) | 2005-02-17 | — | — | US | disclosed |
| US-6818631-B1 | 4-FLUOROALKYL SUBSTITUENT; AGRICULTURE, HORTICULTURE; PLANT DISEASE CONTROL | NIPPON SODA CO. LTD. (JP) | 2004-11-16 | — | — | US | disclosed |
| EP-1196411-A1 | BRADYKININ B1 RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005783-A1 | BRADYKININ B1 RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122882-A1 | Substituted Pyrrolo-Pyrimidine Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | DCK, MAP3K19, MAP3K5 | KDM4C 1575/4885CDK5 63/4885CDK5R1 248/4885 |
| US-20050038041-A1 | Fungicidal pyrimidine derivatives | CBR3, CBR1, TH | KDM4C 648/4885CDK5 349/4885CDK5R1 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.