SCHEMBL456749

SCHEMBL456749

Cc1cn(CC(=O)O)c(=O)[nH]c1=O

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.57
MAPK1 P28482 1/20 0.54
TYMP P19971 1/20 0.50
TK1 P04183 3/20 0.49
TK2 O00142 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL9298238 0.95 HPGD (0.53) HPGDMAPK1TYMPTK1TK2
SCHEMBL17013819 0.87 MAPK1 (0.56) HPGDMAPK1TYMPTK1
SCHEMBL11983370 0.86 MAPK1 (0.54) HPGDMAPK1TYMPTK1
SCHEMBL5353008 0.84 HPGD (0.55) HPGDMAPK1TYMPTK1
SCHEMBL26040009 0.84 HPGD (0.55) HPGDMAPK1TYMPTK1TK2
SCHEMBL452185 0.84 MAPK1 (0.53) HPGDMAPK1TYMPTK1
SCHEMBL905269 0.83 LMNA (0.49) HPGDMAPK1TYMPTK1TK2
SCHEMBL7643586 0.83 MAPK1 (0.51) HPGDMAPK1TYMPTK1
SCHEMBL2153004 0.83 TYMP (0.55) HPGDMAPK1TYMPTK1TK2
SCHEMBL456976 0.83 KDM4E (0.44) HPGDMAPK1TYMPTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 527 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120020170-A Self-gelling hyaluronic acid-based physical crosslinked hydrogel as well as preparation method and application thereof 天津大学 2025-05-20 CN claimed
CN-117659431-A Modified cobalt-based metal organic framework and application thereof in mercury ion detection 沈阳药科大学 2024-03-08 CN claimed
CN-114685605-A Synthetic method of peptide nucleic acid thymine monomer 苏州怡彼得生物技术有限公司 2022-07-01 CN claimed
CN-109675056-B Controlled release system based on base pairing rule and preparation method and application thereof 南京师范大学 2022-03-18 CN claimed
US-10421728-B2 Peptide nucleic acid monomer and a preparation method AMRITA VISHWA VIDYAPEETHAM (IN) 2019-09-24 US claimed
US-20190262794-A1 SUBSTRATES, SYSTEMS, AND METHODS FOR NUCLEIC ACID ARRAY SYNTHESIS VIBRANT HOLDINGS, LLC 2019-08-29 US claimed
US-20180354911-A1 PEPTIDE NUCLEIC ACID MONOMER AND A PREPARATION METHOD AMRITA VISHWA VIDYAPEETHAM (IN) 2018-12-13 US claimed
EP-3402897-A1 SUBSTRATES, SYSTEMS, AND METHODS FOR NUCLEIC ACID ARRAY SYNTHESIS Vibrant Holdings, LLC (US) 2018-11-21 EP claimed
WO-2017117292-A1 SUBSTRATES, SYSTEMS, AND METHODS FOR NUCLEIC ACID ARRAY SYNTHESIS VIBRANT HOLDINGS, LLC (US) 2017-07-06 WO claimed
US-20090298870-A1 PODOPHYLLOTOXIN DERIVATIVES Sutter West Bay Hospitals, dba California Pacific Medical Center and Catholic Healthcare West 2009-12-03 US claimed
US-20050171346-A1 Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation AVENTIS PHARMA S.A. (FR) 2005-08-04 US claimed
EP-0792283-A1 SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH CHIRON CORPORATION (US) 1997-09-03 EP claimed
WO-1996015143-A1 SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH CHIRON CORPORATION (US) 1996-05-23 WO claimed
US-5462976-A Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) 1995-10-31 US claimed
WO-2026101867-A1 PROCESS FOR PREPARING A MACROCYCLIC DIAMINE, INTERMEDIATES, AND CRYSTALLINE FORMS THEREOF MERCK SHARP & DOHME LLC (US) 2026-05-15 WO disclosed
CN-119019837-B Self-repairing material assembled by nucleobase pairs and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2026-05-12 CN disclosed
US-20260072035-A1 ENHANCED SPECIFICITY MASS TAG DNA ADDUCTOMICS UNIV NORTHEASTERN (US) 2026-03-12 US disclosed
WO-1992020703-A1 THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES BUCHARDT OLE (DK) 1992-11-26 WO disclosed
US-4008221-A BACTERICIDE, ANTIBIOTIC RICHARDSON-MERRELL INC. (US) 1977-02-15 US disclosed
US-3956288-A 7-[(2,4-Dioxo-1-pyrimidinyl)acylamino]cephalosporin derivatives RICHARDSON-MERRELL INC. (US) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180354911-A1 PEPTIDE NUCLEIC ACID MONOMER AND A PREPARATION METHOD NPPA, ADAR, NSUN3 HPGD 3598/4885MAPK1 2206/4885TYMP 1410/4885
US-10421728-B2 Peptide nucleic acid monomer and a preparation method NPPA, ADAR, NSUN3 HPGD 3598/4885MAPK1 2206/4885TYMP 1410/4885
US-20260072035-A1 ENHANCED SPECIFICITY MASS TAG DNA ADDUCTOMICS DNMT3A, APEX1, CHAMP1 HPGD 1996/4885MAPK1 1142/4885TYMP 350/4885
US-20050171346-A1 Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation HEXD, CDK5, CHUK HPGD 114/4885MAPK1 88/4885TYMP 359/4885
US-20090298870-A1 PODOPHYLLOTOXIN DERIVATIVES APEH, DAGLA, DPY30 HPGD 1192/4885MAPK1 4510/4885TYMP 1172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.