Sugi Predict

Sugi Predict / Compounds / SCHEMBL4569067

SCHEMBL4569067

SCHEMBL4569067

CC(C)CCOc1cccc(CCCN2C(=O)c3ccccc3C2=O)c1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 3/20 0.57
▸ RAB9A P51151 5/20 0.54
▸ MAPT P10636 3/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.54
▸ TDP1 Q9NUW8 2/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ HPGD P15428 2/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.46
▸ CASP3 P42574 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ NR1H2 P55055 1/20 0.43
▸ NR1H3 Q13133 1/20 0.43
▸ PTGDR2 Q9Y5Y4 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ CYP1B1 Q16678 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2202629 0.87 RAB9A (0.65) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2206692 0.86 RAB9A (0.57) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2202509 0.86 RAB9A (0.57) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2210372 0.86 RAB9A (0.57) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2204230 0.85 RAB9A (0.63) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2209458 0.85 L3MBTL1 (0.76) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2208811 0.84 RAB9A (0.58) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL4569072 0.83 RAB9A (0.53) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2207829 0.82 L3MBTL1 (0.49) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1
SCHEMBL2206329 0.82 GRM5 (0.61) L3MBTL1RAB9AMAPTSMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 — — US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 — — US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 — — US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 — — US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 — — US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 — — US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 — — US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 — — US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 — — US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 — — EP disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 — — US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 — — US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 — — US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 — — US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 — — US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 — — US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 — — US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 — — US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 — — US disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER L3MBTL1 2438/4885RAB9A 2078/4885MAPT 40/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER L3MBTL1 2398/4885RAB9A 2120/4885MAPT 46/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.