SCHEMBL4569733

SCHEMBL4569733

COc1c(OC[C@H]2CO2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
MAPT P10636 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
POLB P06746 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
CHRM4 P08173 1/20 0.36
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
GAA P10253 1/20 0.36
KDM4E B2RXH2 3/20 0.36
KMT2A Q03164 2/20 0.36
HPGD P15428 1/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4535709 1.00 ALDH1A1 (0.38) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL1655549 0.91 DRD4 (0.37) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL1655359 0.91 ADRA2C (0.39) ALDH1A1MAPTGAAKDM4EHPGD
SCHEMBL1656685 0.90 DRD4 (0.41) ALDH1A1KDM4E
SCHEMBL1655935 0.89 DRD4 (0.40) GAA
SCHEMBL83685 0.89 MAPT (0.46) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL6730444 0.87 MAPT (0.39) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL1497638 0.87 MAPT (0.39) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL1658265 0.87 MAPT (0.38) ALDH1A1MAPTSMN1; SMN2POLBTSHR
SCHEMBL30137686 0.87 RAB9A (0.45) ALDH1A1MAPTSMN1; SMN2POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638045-B1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER IP GMBH (DE) 2022-08-31 EP disclosed
US-9902727-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-02-27 US disclosed
US-9902727-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-02-27 US disclosed
EP-2638044-B1 ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES BAYER IP GMBH (DE) 2017-08-30 EP disclosed
US-9730943-B2 Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-08-15 US disclosed
US-9730943-B2 Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-08-15 US disclosed
US-9675616-B2 Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-06-13 US disclosed
US-9675616-B2 Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-06-13 US disclosed
EP-2638043-B1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER IP GMBH (DE) 2017-06-07 EP disclosed
US-20150080374-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-19 US disclosed
US-20150080374-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-19 US disclosed
US-8895549-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-11-25 US disclosed
US-8895549-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-11-25 US disclosed
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-04-24 US disclosed
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-04-24 US disclosed
EP-2638045-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS Bayer Intellectual Property GmbH (DE) 2013-09-18 EP disclosed
WO-2012062748-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-18 WO disclosed
WO-2012062748-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150080374-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS PIK3CA, PIK3CD, PIK3C2A ALDH1A1 2891/4885MAPT 2910/4885SMN1; SMN2 3755/4885
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES VEGFA, CCNA1, CCND2 ALDH1A1 105/4885MAPT 3127/4885SMN1; SMN2 1234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.