Sugi Predict

Sugi Predict / Compounds / SCHEMBL4570035

SCHEMBL4570035

SCHEMBL4570035

COC(=O)Nc1ccc(N2CCCC3(CCN([C@H]4CC[C@H](O)CC4)C3=O)C2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AADAT Q8N5Z0 1/20 0.40
▸ DDB1 Q16531 1/20 0.40
▸ CRBN Q96SW2 1/20 0.40
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ TP53 P04637 2/20 0.39
▸ HPGD P15428 1/20 0.39
▸ MAPT P10636 7/20 0.38
▸ ALDH1A1 P00352 6/20 0.38
▸ KMT2A Q03164 4/20 0.38
▸ RAB9A P51151 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ GAA P10253 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ NFKB1 P19838 1/20 0.38
▸ NFKB2 Q00653 1/20 0.38
▸ RELA Q04206 1/20 0.38
▸ LMNA P02545 2/20 0.37
▸ ALOX15 P16050 2/20 0.37
▸ HSD17B10 Q99714 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4570085 0.91 L3MBTL1 (0.40) AADATDDB1CRBNSMN1; SMN2TP53
SCHEMBL17082070 0.91 L3MBTL1 (0.40) AADATDDB1CRBNSMN1; SMN2TP53
SCHEMBL4570026 0.91 MAPT (0.38) AADATDDB1CRBNSMN1; SMN2TP53
SCHEMBL549440 0.90 MAPT (0.50) AADATDDB1CRBNHPGDMAPT
SCHEMBL549439 0.90 MAPT (0.50) AADATDDB1CRBNHPGDMAPT
SCHEMBL2699537 0.89 DDB1 (0.38) AADATDDB1CRBNSMN1; SMN2TP53
SCHEMBL2699532 0.89 DDB1 (0.38) AADATDDB1CRBNSMN1; SMN2TP53
SCHEMBL549923 0.87 ALDH1A1 (0.45) DDB1CRBNMAPTALDH1A1KMT2A
SCHEMBL549924 0.87 ALDH1A1 (0.45) DDB1CRBNMAPTALDH1A1KMT2A
SCHEMBL4570034 0.86 SMN1; SMN2 (0.39) AADATDDB1CRBNSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1812005-B1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORP (US) 2015-09-16 — — EP disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 AADAT 1625/4885DDB1 3426/4885CRBN 2898/4885
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 AADAT 1625/4885DDB1 3426/4885CRBN 2898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.