Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927520 | 0.77 | THRA (0.37) | ALOX15ALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL1551321 | 0.70 | ALDH1A1 (0.48) | ALOX15ALDH1A1PTGDR2GAASMN1; SMN2 | |
| SCHEMBL20581735 | 0.68 | ALDH1A1 (0.47) | ALOX15ALDH1A1PTGDR2GAATNF | |
| SCHEMBL20581734 | 0.68 | ALDH1A1 (0.47) | ALOX15ALDH1A1PTGDR2GAATNF | |
| SCHEMBL5711904 | 0.66 | ALDH1A1 (0.53) | ALDH1A1GAASMN1; SMN2KDM4ETSHR | |
| SCHEMBL6247630 | 0.66 | TSHR (0.58) | ALDH1A1GAAKDM4ETSHRRAB9A | |
| Malic Acid SCHEMBL174846 | 0.65 | KDM6B (0.51) | ALOX15ALDH1A1KMOGAASMN1; SMN2 | |
| Malic Acid SCHEMBL4570540 | 0.65 | KDM6B (0.51) | ALOX15ALDH1A1KMOGAASMN1; SMN2 | |
| SCHEMBL9167266 | 0.65 | ALOX15 (0.62) | ALOX15ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL6860845 | 0.64 | PTGS1 (0.66) | ALDH1A1GAASMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017848-A9 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009017848-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC. (US) | 2009-02-05 | — | — | WO | disclosed |