Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047347 | 0.79 | SLC6A9 (0.42) | ALDH1A1KDM4ELMNAHTR6CNR2 | |
| SCHEMBL10607953 | 0.78 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL9766413 | 0.77 | ADRB1 (0.58) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL31531621 | 0.76 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL4573220 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL532144 | 0.75 | ALDH1A1 (0.69) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL4518266 | 0.75 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAHTR6ADRB1 | |
| SCHEMBL17968961 | 0.74 | ADRB1 (0.49) | ALDH1A1KDM4ELMNAADRB1SIRT6 | |
| SCHEMBL19485484 | 0.74 | ADRB1 (0.49) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17834368 | 0.74 | ADRB1 (0.49) | ALDH1A1KDM4ELMNAADRB1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |