Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.47 |
| ▸ | HTR3B | O95264 | 4/20 | 0.47 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117698 | 0.84 | PRKCQ (0.41) | — | |
| SCHEMBL26076035 | 0.79 | HTR3E (0.51) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4573932 | 0.79 | UCHL3 (0.42) | ALDH1A1KDM4EHSD17B10HRH3 | |
| SCHEMBL31651657 | 0.78 | HTR3E (0.50) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL16422608 | 0.78 | HTR3E (0.51) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2875379 | 0.78 | HTR3E (0.50) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL26074527 | 0.75 | ADRB2 (0.49) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL26075869 | 0.75 | HTR3E (0.48) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5585294 | 0.74 | ADRB2 (0.62) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4573681 | 0.74 | MAP4K4 (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |