Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 4/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573226 | 0.84 | ADRB1 (0.47) | — | |
| SCHEMBL4573826 | 0.83 | ZAP70 (0.45) | PRKCQPRKCDACVR1ZAP70PIM1 | |
| SCHEMBL8113211 | 0.81 | ROCK2 (0.39) | ACVR1FGFR1FGFR2FGFR3ZAP70 | |
| SCHEMBL4573273 | 0.79 | ZAP70 (0.39) | PRKCQPRKCDACVR1FGFR1FGFR2 | |
| SCHEMBL4590384 | 0.79 | ZAP70 (0.39) | PRKCQPRKCDACVR1FGFR1FGFR2 | |
| SCHEMBL4573978 | 0.77 | HTR2A (0.32) | — | |
| SCHEMBL4573074 | 0.75 | CTSB (0.45) | — | |
| SCHEMBL14404436 | 0.74 | PRKCQ (0.47) | PRKCQPRKCDACVR1ZAP70PIM1 | |
| SCHEMBL8123583 | 0.73 | ZAP70 (0.45) | PRKCQPRKCDACVR1FGFR1FGFR2 | |
| SCHEMBL4573161 | 0.73 | GHSR (0.46) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |