Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573225 | 1.00 | HRH4 (0.40) | HRH4CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4573273 | 0.78 | ZAP70 (0.39) | HRH4ZAP70ACVR1FGFR1FGFR2 | |
| SCHEMBL4590384 | 0.78 | ZAP70 (0.39) | HRH4ZAP70ACVR1FGFR1FGFR2 | |
| SCHEMBL4573206 | 0.75 | PIK3CD (0.38) | KIT | |
| SCHEMBL3878732 | 0.73 | MAPK13 (0.41) | HRH4KITZAP70PRKCIMAPK13 | |
| SCHEMBL3878731 | 0.73 | MAPK13 (0.41) | HRH4KITZAP70PRKCIMAPK13 | |
| SCHEMBL8108577 | 0.72 | MAP4K4 (0.46) | — | |
| SCHEMBL4573909 | 0.72 | MAP4K4 (0.46) | — | |
| SCHEMBL14318088 | 0.70 | HRH4 (0.41) | HRH4KITPRKCIMAPK13MAPK12 | |
| SCHEMBL8113211 | 0.70 | ROCK2 (0.39) | HRH4ZAP70ACVR1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |