Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | IDH1 | O75874 | 5/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108577 | 0.86 | MAP4K4 (0.46) | PIK3CDIDH1GRM1 | |
| SCHEMBL4573909 | 0.86 | MAP4K4 (0.46) | PIK3CDIDH1GRM1 | |
| SCHEMBL4573360 | 0.84 | KIT (0.37) | PIK3CDCHRM4KITPIK3R1GRM1 | |
| SCHEMBL4573182 | 0.80 | PIK3CD (0.41) | PIK3CDCHRM4PIK3R1GRM1CNR2 | |
| SCHEMBL4573257 | 0.75 | HRH4 (0.40) | KIT | |
| SCHEMBL4573559 | 0.75 | HRH3 (0.45) | PIK3CDCHRM4PIK3R1GRM1 | |
| SCHEMBL4573225 | 0.75 | HRH4 (0.40) | KIT | |
| SCHEMBL4572967 | 0.73 | CHRM4 (0.46) | PIK3CDCHRM4PIK3R1GRM1 | |
| SCHEMBL4573864 | 0.73 | CHRM4 (0.57) | CHRM4KIT | |
| SCHEMBL4573353 | 0.71 | CTSB (0.42) | GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |