Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 6/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108577 | 1.00 | MAP4K4 (0.46) | MAP4K4GPR119SUV39H2HDAC1IDH1 | |
| SCHEMBL4573206 | 0.86 | PIK3CD (0.38) | IDH1GRM1PIK3CD | |
| SCHEMBL8116228 | 0.86 | MAP4K4 (0.48) | MAP4K4GPR119SUV39H2HDAC1NR1H2 | |
| SCHEMBL4584298 | 0.86 | MAP4K4 (0.48) | MAP4K4GPR119SUV39H2HDAC1NR1H2 | |
| SCHEMBL4573072 | 0.82 | MAP4K4 (0.51) | MAP4K4GPR119SUV39H2HDAC1GRM1 | |
| SCHEMBL4573109 | 0.82 | MAP4K4 (0.51) | MAP4K4GPR119SUV39H2HDAC1GRM1 | |
| SCHEMBL8113244 | 0.78 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1NR1H2 | |
| SCHEMBL4584408 | 0.78 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1NR1H2 | |
| SCHEMBL8108991 | 0.76 | GPR119 (0.51) | MAP4K4GPR119SUV39H2HDAC1PIK3CD | |
| SCHEMBL4573572 | 0.76 | GPR119 (0.51) | MAP4K4GPR119SUV39H2HDAC1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |