Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573273 | 1.00 | ZAP70 (0.39) | ZAP70HRH4ACVR1FGFR1FGFR2 | |
| SCHEMBL8117698 | 0.79 | PRKCQ (0.41) | ZAP70ACVR1FGFR1FGFR2FGFR3 | |
| SCHEMBL4573257 | 0.78 | HRH4 (0.40) | ZAP70HRH4ACVR1FGFR1FGFR2 | |
| SCHEMBL4573225 | 0.78 | HRH4 (0.40) | ZAP70HRH4ACVR1FGFR1FGFR2 | |
| SCHEMBL4573182 | 0.75 | PIK3CD (0.41) | — | |
| SCHEMBL8113211 | 0.75 | ROCK2 (0.39) | ZAP70HRH4ACVR1FGFR1FGFR2 | |
| SCHEMBL4573826 | 0.74 | ZAP70 (0.45) | ZAP70ACVR1PRKCQPRKCDPIM1 | |
| SCHEMBL8123583 | 0.72 | ZAP70 (0.45) | ZAP70ACVR1FGFR1FGFR2FGFR3 | |
| SCHEMBL23744101 | 0.71 | NPC1 (0.48) | ZAP70HRH4PRKCQPRKCD | |
| SCHEMBL30345769 | 0.71 | NPC1 (0.48) | ZAP70HRH4PRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |