Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113244 | 0.85 | MAP4K4 (0.52) | HRH3CXCR3GRM1CHRM4PIK3CG | |
| SCHEMBL4584408 | 0.85 | MAP4K4 (0.52) | HRH3CXCR3GRM1CHRM4PIK3CG | |
| SCHEMBL4573088 | 0.82 | CHRM4 (0.58) | HRH3GRM1CHRM4ROCK2PRKG1 | |
| SCHEMBL26089447 | 0.81 | HCAR2 (0.39) | HRH3CXCR3CHRM4PIK3CGFFAR4 | |
| SCHEMBL26088683 | 0.81 | HCAR2 (0.39) | HRH3CXCR3CHRM4PIK3CGFFAR4 | |
| SCHEMBL4574771 | 0.80 | HRH3 (0.39) | HRH3CXCR3GRM1CHRM4PIK3CG | |
| SCHEMBL4573360 | 0.77 | KIT (0.37) | GRM1CHRM4PIK3CDROCK2PRKG1 | |
| SCHEMBL4574023 | 0.77 | PIK3CD (0.43) | GRM1PIK3CGPIK3CDROCK2PRKG1 | |
| SCHEMBL4573206 | 0.75 | PIK3CD (0.38) | GRM1CHRM4PIK3CDPIK3R1 | |
| SCHEMBL4573182 | 0.75 | PIK3CD (0.41) | GRM1CHRM4PIK3CGPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |