Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.38 |
| ▸ | GRK4 | P32298 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573072 | 0.86 | MAP4K4 (0.51) | PIK3CDCTSBCTSSCTSKPIK3R1 | |
| SCHEMBL4573109 | 0.86 | MAP4K4 (0.51) | PIK3CDCTSBCTSSCTSKPIK3R1 | |
| SCHEMBL4574023 | 0.84 | PIK3CD (0.43) | PIK3CDCTSBCTSSCTSKPIK3R1 | |
| SCHEMBL4573074 | 0.81 | CTSB (0.45) | CTSBCTSSCTSKGRM1MAP4K4 | |
| SCHEMBL4573206 | 0.80 | PIK3CD (0.38) | PIK3CDPIK3R1GRM1CNR2CHRM4 | |
| SCHEMBL4572967 | 0.78 | CHRM4 (0.46) | PIK3CDPIK3R1GRM1CHRM4 | |
| SCHEMBL4573077 | 0.76 | CTSB (0.44) | CTSBCTSSCTSKGRM1MAP4K4 | |
| SCHEMBL4573353 | 0.76 | CTSB (0.42) | CTSBCTSSCTSKGRM1 | |
| SCHEMBL4573273 | 0.75 | ZAP70 (0.39) | — | |
| SCHEMBL4590384 | 0.75 | ZAP70 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |