Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 3/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116228 | 0.86 | MAP4K4 (0.48) | KITPIK3CDGRM1 | |
| SCHEMBL4584298 | 0.86 | MAP4K4 (0.48) | KITPIK3CDGRM1 | |
| SCHEMBL4573206 | 0.84 | PIK3CD (0.38) | KITPIK3CDPI4KBCHRM4PIK3R1 | |
| SCHEMBL4574023 | 0.79 | PIK3CD (0.43) | PIK3CDPIK3R1ROCK2PRKG1GRM1 | |
| SCHEMBL4573559 | 0.77 | HRH3 (0.45) | PIK3CDCHRM4PIK3R1ROCK2PRKG1 | |
| SCHEMBL31111640 | 0.75 | CHRNB2 (0.46) | CHRM4GRM1 | |
| SCHEMBL4573864 | 0.75 | CHRM4 (0.57) | KITCHRM4ROCK2PRKG1 | |
| SCHEMBL4573090 | 0.74 | CHRM4 (0.45) | PIK3CDCHRM4PIK3R1GRM1 | |
| SCHEMBL25187577 | 0.73 | GRM1 (0.45) | PIK3CDCHRM4PIK3R1GRM1 | |
| SCHEMBL27697487 | 0.72 | CHRM1 (0.43) | CHRM4GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |