Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108991 | 1.00 | GPR119 (0.51) | GPR119MAP4K4CHRM4HDAC1SUV39H2 | |
| SCHEMBL4572967 | 0.86 | CHRM4 (0.46) | CHRM4HCRTR2PIK3CDPIK3R1 | |
| SCHEMBL4584304 | 0.86 | GPR119 (0.52) | GPR119MAP4K4CHRM4HDAC1SUV39H2 | |
| SCHEMBL4584302 | 0.86 | GPR119 (0.52) | GPR119MAP4K4CHRM4HDAC1SUV39H2 | |
| SCHEMBL8109939 | 0.85 | MAP4K4 (0.56) | GPR119MAP4K4CHRM4HDAC1SUV39H2 | |
| SCHEMBL4573828 | 0.85 | MAP4K4 (0.56) | GPR119MAP4K4CHRM4HDAC1SUV39H2 | |
| SCHEMBL8107805 | 0.80 | HDAC1 (0.49) | GPR119MAP4K4HDAC1SUV39H2PIK3CD | |
| SCHEMBL4573072 | 0.80 | MAP4K4 (0.51) | GPR119MAP4K4HDAC1SUV39H2PIK3CD | |
| SCHEMBL4573109 | 0.80 | MAP4K4 (0.51) | GPR119MAP4K4HDAC1SUV39H2PIK3CD | |
| SCHEMBL23560775 | 0.78 | GPR119 (0.62) | GPR119MAP4K4HDAC1SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |