Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573109 | 1.00 | MAP4K4 (0.51) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL4573182 | 0.86 | PIK3CD (0.41) | MAP4K4PIK3CDGRM1CTSBCTSS | |
| SCHEMBL4573401 | 0.86 | MAP4K4 (0.52) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL8117739 | 0.86 | MAP4K4 (0.52) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL4573828 | 0.83 | MAP4K4 (0.56) | MAP4K4HDAC1GPR119SUV39H2GRM1 | |
| SCHEMBL8109939 | 0.83 | MAP4K4 (0.56) | MAP4K4HDAC1GPR119SUV39H2GRM1 | |
| SCHEMBL4573909 | 0.82 | MAP4K4 (0.46) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL8108577 | 0.82 | MAP4K4 (0.46) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL4573572 | 0.80 | GPR119 (0.51) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 | |
| SCHEMBL8108991 | 0.80 | GPR119 (0.51) | MAP4K4HDAC1GPR119PIK3CDSUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |