Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 6/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573992 | 0.87 | MAPK1 (0.44) | PRKCISCN9ACYP2C9CYP2C19MAPK1 | |
| SCHEMBL14104167 | 0.86 | KDM4E (0.35) | PRKCISCN9ACYP2C9CYP2C19MET | |
| SCHEMBL4738829 | 0.86 | NR1I3 (0.40) | PRKCISCN9ACYP2C9CYP2C19MAPK1 | |
| SCHEMBL9881228 | 0.85 | PRKCI (0.43) | PRKCICYP2C9CYP2C19KDR | |
| SCHEMBL4743431 | 0.84 | MAPK1 (0.40) | CYP2C9CYP2C19MAPK1 | |
| SCHEMBL4740295 | 0.84 | PTGS1 (0.40) | PRKCISCN9ACYP2C9CYP2C19MET | |
| SCHEMBL14104079 | 0.83 | CYP1A2 (0.36) | PRKCISCN9ACYP2C9CYP2C19ICMT | |
| SCHEMBL11990372 | 0.83 | AR (0.39) | PRKCISCN9ACYP2C9CYP2C19ICMT | |
| SCHEMBL14103888 | 0.82 | PIK3CA (0.37) | PRKCISCN9ACYP2C9CYP2C19MET | |
| SCHEMBL14103801 | 0.82 | PIK3CA (0.43) | PRKCISCN9ACYP2C9CYP2C19ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |