Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574802 | 0.82 | OPRK1 (0.56) | OPRK1HDAC6HDAC1HDAC8TACR1 | |
| SCHEMBL8574805 | 0.82 | OPRK1 (0.56) | OPRK1HDAC6HDAC1HDAC8TACR1 | |
| SCHEMBL4574178 | 0.79 | OPRK1 (0.38) | OPRK1HDAC6HDAC1HDAC8TACR1 | |
| SCHEMBL6717771 | 0.74 | OPRK1 (0.57) | OPRK1HDAC6HDAC1HDAC8 | |
| SCHEMBL4293912 | 0.72 | HDAC6 (0.60) | OPRK1HDAC6HDAC1HDAC8TACR1 | |
| SCHEMBL3504268 | 0.71 | GHSR (0.46) | OPRK1CYP3A4TSHRLMNA | |
| SCHEMBL3504617 | 0.71 | GHSR (0.46) | OPRK1CYP3A4TSHRLMNA | |
| SCHEMBL3504265 | 0.71 | GHSR (0.46) | OPRK1CYP3A4TSHRLMNA | |
| SCHEMBL4292380 | 0.70 | OPRK1 (0.59) | OPRK1HDAC6HDAC1HDAC8TACR1 | |
| SCHEMBL14033005 | 0.70 | OPRK1 (0.61) | OPRK1HDAC6HDAC1HDAC8TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |