Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074503 | 0.85 | POLB (0.45) | HSD17B10MAPTTP53KMT2AALDH1A1 | |
| SCHEMBL5922311 | 0.76 | CHRNA7 (0.61) | LMNAMAPK1MAPTTP53KMT2A | |
| SCHEMBL5922387 | 0.74 | THRB (0.58) | LMNAMAPK1MAPTTP53KMT2A | |
| SCHEMBL7488349 | 0.73 | KMT2A (0.67) | LMNATP53KMT2AUSP2HTT | |
| SCHEMBL5922363 | 0.72 | MAPK1 (0.60) | LMNAMAPK1MAPTTP53KMT2A | |
| SCHEMBL4573897 | 0.72 | TSHR (0.42) | LMNAHSD17B10MAPK1MAPTKMT2A | |
| SCHEMBL15614376 | 0.72 | ALDH1A1 (0.53) | LMNAMAPTTP53HTTALDH1A1 | |
| SCHEMBL29191709 | 0.70 | MEN1 (0.62) | LMNAHSD17B10MAPK1NPSR1MAPT | |
| SCHEMBL1546951 | 0.69 | KMT2A (0.57) | LMNAMAPTKMT2AUSP2HTT | |
| SCHEMBL23635829 | 0.67 | ALDH1A1 (0.51) | LMNAHSD17B10MAPK1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319084-B2 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2006-08-10 | — | — | US | disclosed |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY (US) | 2005-03-10 | — | — | US | disclosed |
| US-6825356-B2 | REMAINING DONOR ATOMS OF THE LIGAND ARE SELECTED FROM THE GROUP CONSISTING OF C, N, P, AS, O, S, AND SE | EASTMAN CHEMICAL COMPANY | 2004-11-30 | — | — | US | disclosed |
| US-20030225228-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY | 2003-12-04 | — | — | US | disclosed |
| US-20030195110-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-10-16 | — | — | US | disclosed |
| US-6559091-B1 | Metal complex ligated by a monodentate, bidentate, tridentate, or tetradentate ligand, wherein at least one of the donor atoms of the ligand is a nitrogen atom substituted by a 1-pyrrolyl or substituted 1- pyrrolyl group | EASTMAN CHEMICAL COMPANY | 2003-05-06 | — | — | US | disclosed |
| US-6545108-B1 | Ti, Zr, Hf, Cr, Mo, W, V, Nb, or Ta complex of a monodentate dianionic ligand in which a nitrogen atom is substituted by a 1-pyrrolyl and the remaining donor atoms are N, P, As, O, S, or Se | EASTMAN CHEMICAL COMPANY | 2003-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | LMNA 3523/4885HSD17B10 2880/4885MAPK1 4161/4885 |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | LMNA 3523/4885HSD17B10 2880/4885MAPK1 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.